![]() ![]() Thus, care should be taken when interpreting these results to avoid unnecessary testing. □An R ratio of >5 is defined as hepatocellular, <2 is cholestatic, and 2–5 is a mixed pattern.The actual function of the liver can be graded based on its ability to produce albumin as well as vitamin K-dependent clotting factors.Įlevated liver function tests found in near 8% of the general population.These elevations may be transient in patients without symptoms, with up to 30% of elevations resolving after 3 weeks. The R ratio calculated by the formula R = (ALT value÷ALT ULN)÷(alkaline phosphatase value÷alkaline phosphatase ULN). □The R ratio has been used to assess whether the pattern of liver injury is hepatocellular, cholestatic or mixed. ✔️Isolated #hyperbilirubinemia defined as an elevation of bilirubin with normal ALP & AST/ALT. ✔️A #mixed injury pattern is defined as an elevation of ALP as well as AST/ALT levels. ✔️⬆️ in ALP & bilirubin in disproportion to ALT & AST would indicate a #cholestatic pattern. ✔️⬆️ in ALT& AST in out of proportion to ALP & bilirubin, denotes a #hepatocellular disease. ♦️These tests can help determine an area of the #liver where damage may be taking place and, depending on the pattern of elevation, can help organize a differential diagnosis. ♦️The liver function tests typically include alanine transaminase ( #ALT) & aspartate transaminase ( #AST), alkaline phosphatase ( #ALP), gamma glutamyl transferase ( #GGT), serum #bilirubin, prothrombin time ( #PT), international normalized ratio( #INR),total #protein & #albumin. ♦️The term "liver function tests " or LFT is a misnomer as many of the tests do not comment on function of the liver but rather pinpoint the source of the damage. ♦️Since majority of the general population have heard of liver function tests,I'm going to simplify it, in a way it would be useful for #healthcare as well as non-healthcare professionals□
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